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| autoid | 104 |
| crg_id | CRG020600040 |
| titleoftrial | Evaluation of hydrochlorothiazide and furosemide as nephroprotective agents in chronic kidney disease stages 3 and 4 |
| acronymnoftrial | SEDATIF 2 (Study of the Efficacy of Diuretics in Advanced and preTerminal renal failure |
| website | http:// |
| identificationno | |
| leadprefix | Prof |
| leadsurname | Bertrand |
| leadgivennames | DUSSOL |
| leadposition | MD, PhD |
| leaddepartment | Nephrology |
| leadorganisation | Assistance Publique Marseille |
| leadaddress | Hospital de la Conception, 147 Bd Baille, 13005 MARSEILLE |
| leademail | bdussol@ap-hm.fr |
| leadphone | +33 4 91 38 30 43 |
| leadfax | +33 4 91 38 32 06 |
| leadsuffix | |
| contactprefix | |
| contactsurname | |
| contactgivennames | |
| contactposition | |
| contactdepartment | |
| contactorganisation | |
| contactaddress | |
| contactemail | |
| contactphone | |
| contactfax | |
| funding | govt |
| otherfunding | |
| fundingnameofsponsors | |
| ethicsapproval | yes |
| studytype | randomised |
| studytype_other | |
| groupassignment | crossover |
| blinding_patients | yes |
| blinding_investigators | yes |
| blinding_outcomes | yes |
| blinding_analysts | yes |
| proposedstart | 06/2005 |
| actualstart | |
| proposedcompletiondate | 12/2006 |
| actualcompletiondate | |
| multi_center_study | no |
| numberofcentres | |
| multi_national_study | no |
| countrycentres | France |
| researchquestion | Does hydrochlorothiazide decrease filtration fraction (GFR/RBF) in CKD (stage 3 and 4) patients?
Does hydrochlorothiazide increase the fractional excretion of Na more than furosemide in CKD (stage 3 and 4) patients? |
| study_status_recruitment | ongoing |
| study_status_recruitment_follow | ongoing |
| healthcarecondition | chronic kidney disease stage 3 and 4 |
| intervention1 | hydrochlorothiazide and furosemide |
| intervention2 | |
| intervention3 | |
| intervention4 | |
| participants_gender | both |
| participants_other | adults |
| age | From 18 to 80 years old |
| totalrecruitment | 40 |
| inclusion | Hypertensive patients with Cockcroft clearance between 15 and 60 ml/min |
| exclusion | |
| primaryoutcomes | Alterations of Filtration Fraction (FF) under hydrochlorothiazide and furosemide |
| secondaryoutcomes | Alterations of Fractional Excretion of Na and Cl (FeNa, FeCl) under hydrochlorothiazide and furosemide |
| reference | B. Dussol et al. A randomized trial of furosemide vs hydrochlorothiazide in patients with chronic renal failure and hypertension. Nephrol Dial Transplant 2005; 20: 349-353 |