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| autoid | 21 |
| crg_id | CRG080500010 |
| titleoftrial | A Randomised placebo-controlled trial of antibiotics to prevent urinary tract infection in children |
| acronymnoftrial | PRIVENT Prevention of Recurrent urinary tract Infection in children with VEsicouretic reflux and Normal renal Tracts |
| website | http://www.kidney-research.org/privent.html |
| identificationno | 2002/051; ACTRN12608000470392 |
| leadprefix | A/Prof |
| leadsurname | Jonathan |
| leadgivennames | Craig |
| leadposition | Senior Staff Specialist |
| leaddepartment | Centre for Kidney Research |
| leadorganisation | The Children\'s Hospital at Westmead |
| leadaddress | Corner of Hawkwsbury Road and Hainsworth Street, Locked Bag 4001, WESTMEAD NSW 2145 |
| leademail | jonC@chw.edu.au |
| leadphone | +61 2 9845 3431 |
| leadfax | + 61 2 9845 3038 |
| leadsuffix | |
| contactprefix | Ms |
| contactsurname | Lowe |
| contactgivennames | Alison |
| contactposition | Research Assistant |
| contactdepartment | Centre for Kidney Research |
| contactorganisation | The Children\'s Hospital at Westemead |
| contactaddress | Corner of Hawkwsbury Road and Hainsworth Street, Locked Bag 4001, WESTMEAD NSW 2145 |
| contactemail | AlisonL4@chw.edu.au |
| contactphone | +61 2 9845 1468 |
| contactfax | +61 2 9845 3038 |
| funding | ngo |
| otherfunding | |
| fundingnameofsponsors | NHMRC, Financial Markets for Children |
| ethicsapproval | yes |
| studytype | randomised |
| studytype_other | |
| groupassignment | parallel |
| blinding_patients | yes |
| blinding_investigators | yes |
| blinding_outcomes | yes |
| blinding_analysts | yes |
| proposedstart | Dec 1998 |
| actualstart | |
| proposedcompletiondate | Jan 2007 |
| actualcompletiondate | |
| multi_center_study | yes |
| numberofcentres | 4 |
| multi_national_study | no |
| countrycentres | Australia |
| researchquestion | Do long-term antibiotics prevent recurrent urinary tract infectioncs? |
| study_status_recruitment | Recruitment completed |
| study_status_recruitment_follow | Completed |
| healthcarecondition | Urinary tract infection, vesicouretic reflux, antibiotic use |
| intervention1 | Cotrimoxazole |
| intervention2 | Placebo - matched for colour, taste and consistency |
| intervention3 | |
| intervention4 | |
| participants_gender | both |
| participants_other | |
| age | 0 - 18 years |
| totalrecruitment | 780 |
| inclusion | Acute symptomatic urinary infection confirmed by urine culture And at least one of the following: fever, dysuria, frequency, incontinence, febrile convulsions, offensive urine, macroscopic haematuria, malaise, anorexia |
| exclusion | Paediatric bag sample, indwelling catheter, nosocomial UTI\'s, predisposing causes; urological/nephrological, Neurological, Medical treatments - immunosupressed, Children with known haematological disorders, G6PD deficiency, Children withb known sulphur allergy, Non-resident |
| primaryoutcomes | Primary outcome is a repeat symptomatic urinary tract infection confirmed with a urinary culture |
| secondaryoutcomes | Secondary outcomes include possible adverse reactions to the treatment, hospitalisation with UTI, Hospitalisation for causes other than UTI, Antibiotic administration for other infectious diseases, UTI with fever |
| reference | Craig J, Roy L, Sureshkumar P, Burke J, Powell H, et al. Long-term anitbiotics to prevent urinary tract infection in children with isolated vesicoureteric reflux: a placebo-controlled
randomized trial [abstract]. Journal of the American Society of Nephrology. 2002; 13(September, Program & Abstracts) : 3A.
Craig J, Roy L, Burke J, Powell H, Hodson EM, Knight JF, Sureshkumar P. Long-term antibiotics to prevent urinary tract infection in children with isolated vesicoureteric reflux: a placebo-controlled randomized trial [abstract]. Nephrology. 2002; 7(Suppl) : A55. |