Cochrane Renal Group

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autoid 24
crg_id CRG090500013
titleoftrial The Effect of Membrane Permeability on ESRD Patient Outcome
acronymnoftrial MPO Study
website http://
identificationno ISRCTN43474447
leadprefix Prof
leadsurname Locatelli
leadgivennames Francesco
leadposition Director
leaddepartment Department of Nephrology
leadorganisation Ospedale di Lecco
leadaddress via Dell\' Eremo 9/11, 23900 Lecco, Italy
leademail nefrologia@ospedale.lecco.it
leadphone +39 0341 489850
leadfax +39 0341 489860
leadsuffix
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contactsurname
contactgivennames
contactposition
contactdepartment
contactorganisation
contactaddress
contactemail
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funding industry
otherfunding
fundingnameofsponsors
ethicsapproval yes
studytype randomised
studytype_other
groupassignment parallel
blinding_patients no
blinding_investigators no
blinding_outcomes no
blinding_analysts no
proposedstart
actualstart 12/1998
proposedcompletiondate
actualcompletiondate 07/2006
multi_center_study yes
numberofcentres over_55
multi_national_study yes
countrycentres Belarus, Italy
researchquestion To test whether the survival of ESRD patients treated with bicarbonate hemodialysis using high-flux membranes is better than that of those treated with bicarbonate hemodialysis using low-flux membranes.
study_status_recruitment no_longer_recruiting
study_status_recruitment_follow ongoing
healthcarecondition End stage renal disease
intervention1 Hemodialysis with high-flux dialysers
intervention2 Hemodialysis with low-flux dialysers
intervention3
intervention4
participants_gender both
participants_other adults
age 18-80
totalrecruitment 666
inclusion Patients on on renal replacement therapy for less than 2 months
exclusion
primaryoutcomes Patient survival
secondaryoutcomes
reference
  • Locatelli F, Pozzoni P, Di Filippo S. What are we expecting to learn from the MPO study?. [Review] [20 refs]. Contributions to Nephrology. 2005; 149:83-89.
  • Locatelli F, Hannedouche T, Jacobson S, La Greca G, Loureiro A, Martin-Malo A, Papadimitriou M, Vanholder R. The effect of membrane permeability on ESRD: design of a prospective randomised multicentre trial. Journal of Nephrology. 1999 Mar; 12(2):85-88.
  • Locatelli et al. Risk factors for cardiovascular diseases in patients starting dialysis in Northern and Southern Europe: results from the MPO study (Abstract). ASN 2001, EDTA 2002
  • Hannedouche et al. Relationship of residual renal function (RRF) to serum b2-microglobulin and advanced glycation end products in patients starting hemodialysis (HD) [abstract no: A1833] Journal of the American Society of Nephrology 2001; 12:356A
  • Locatelli et al. Patient and treatment characteristics in the MPO study: Validation against the DOPPS population. WCN 2003
  • Vanholder R, Hannedouche T, Jacobson SH, La Greca G, Loureiro A, Martin-Malo A, Papadimitriou M, Locatelli F, MPO Study Group. Male gender as risk factor to be underdialysed: baseline data from the MPO study [abstract no: T221]. Nephrology Dialysis Transplantation 2002; 17 Suppl 1: 250.
  • Martin-Malo A, Czekalski S, Hannedouche T, Jacobson SH, Loureiro A, Papadimitriou M, Ronco C, Vanholder R, Wizemann V, Locatelli F, MPO Study Group. Patient and treatment patterns at start of dialysis: analysis of the effect of age [abstract]. Nephrology Dialysis Transplantation. 2003; 18(Suppl 4) : 196-197
  • Vanholder R, Hannedouche T, Jacobson SH, Ronco C, Loureiro A, Martin-Malo A, Papadimitriou M, Czekalski S, Wizemann V, Locatelli F. Protein catabolic rate (PCR) normalised to ideal body weight (BW) as indicator of protein intake: data from the MPO study. [abstract SA-PO400]. Journal of the American Society of Nephrology. 2004; 15(Oct) : 389A-390A
  • Jacobson SH, Czekalski S, Hannedouche T, Loureiro A, Martin-Malo A, Papadimitriou M, Ronco C, Vanholder R, Wizemann V, Locatelli F. Modifiable cardiovascular risk factors: baseline results of the MPO study. [abstract no: SU-PO367]. Journal of the American Society of Nephrology. 2004; 15(Oct) : 614A.
  • Locatelli F, Martin-Malo A, Hannedouche T, Loureiro A, Papadimitriou M, Wizemann V, Jacobson SH, Czekalski S, Ronco C, Vanholder R, Membrane Permeability Outcome (MPO) Study Group. Effect of Membrane Permeability on Survival of Hemodialysis Patients. Journal of the American Society of Nephrology. 2009; 20(3) : 645-654.
    • [Updated by GYHiggins 1 Mar 2--9]