Back
| autoid | 80 |
| crg_id | CRG110500018 |
| titleoftrial | Soluble receptor for advanced glycation end products (sRAGE) in patients with decreased renal function, its relationship to dialysis modalities |
| acronymnoftrial | Soluble receptor for AGEs and renal function |
| website | http:// |
| identificationno | substudy of grant IGA MH CZ NR/8094-3 |
| leadprefix | Dr |
| leadsurname | Kalousova |
| leadgivennames | Marta |
| leadposition | Associate Professor |
| leaddepartment | Institute of Clinical Chemistry and Laboratory Diagnostics |
| leadorganisation | 1st Faculty of Medicine, Charles University |
| leadaddress | Karlovo nam. 32, 121 11 Prague 2, Czech Republic |
| leademail | marta.kalousova@seznam.cz |
| leadphone | +420 224966620 |
| leadfax | +420 224962848 |
| leadsuffix | |
| contactprefix | Dr |
| contactsurname | Kalousova |
| contactgivennames | Marta |
| contactposition | Associate Professor |
| contactdepartment | Institute of Clinical Chemistry and Laboratory Diagnostics |
| contactorganisation | 1st Faculty of Medicine, Charles University |
| contactaddress | Karlovo nam. 32, 121 11 Prague 2, Czech Republic |
| contactemail | marta.kalousova@seznam.cz |
| contactphone | +420 224966620 |
| contactfax | +420 224962848 |
| funding | govt |
| otherfunding | |
| fundingnameofsponsors | Internal Grant Agency of the Czech Ministery of Health, Czech Republic |
| ethicsapproval | yes |
| studytype | nonrandomised |
| studytype_other | cross sectional study |
| groupassignment | parallel |
| blinding_patients | no |
| blinding_investigators | no |
| blinding_outcomes | no |
| blinding_analysts | no |
| proposedstart | 9/2003 |
| actualstart | 9/2003 |
| proposedcompletiondate | 12/2005 |
| actualcompletiondate | 10/2005 |
| multi_center_study | no |
| numberofcentres | |
| multi_national_study | no |
| countrycentres | Czech Republic |
| researchquestion | Advanced glycation end products (AGEs) accumulate in patients with decreased renal function and exert various toxic effects via RAGE (receptor for AGEs). Soluble RAGE (sRAGE) is a naturally occurring inhibitor of AGE-RAGE action. The aim of the study was to describe the relationship of sRAGE to renal function and dialysis modalities. |
| study_status_recruitment | no_longer_recruiting |
| study_status_recruitment_follow | completed |
| healthcarecondition | chronic kidney diseases, decreased renal function, end stage renal disease |
| intervention1 | observational cross-sectional study |
| intervention2 | hemodialysis and hemodiafiltration in patients on chronic hemodialysis or hemodiafiltration |
| intervention3 | |
| intervention4 | |
| participants_gender | both |
| participants_other | adults |
| age | N/A |
| totalrecruitment | 80-100 incl. healthy controls |
| inclusion | chronic kidney disease
decreased renal function end stage renal disease - chronic peritoneal dialysis or chronic hemodialysis/ hemodiafiltration informed consent of the patient |
| exclusion | unstable clinical status |
| primaryoutcomes | description of the relationship of sRAGE to renal function and dialysis modalities |
| secondaryoutcomes | |
| reference | 1. Kalousova M. Hodkova M. Kazderova M. Fialova J. Tesar V. Dusilova-Sulkova S. Zima T. Soluble receptor for advanced glycation end products in patients with decreased renal function. American Journal of Kidney Diseases. 47(3):406-11, 2006 Mar. [added by gail higgins 20/08/2007] |