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| autoid | 97 |
| crg_id | CRG010600033 |
| titleoftrial | Enhanced expression of glucose transporter 1 on erythrocyte membrane in hemodialysis patients: the possible role in erythrocyte ascorbate recycling |
| acronymnoftrial | |
| website | http:// |
| identificationno | |
| leadprefix | Dr |
| leadsurname | Chen |
| leadgivennames | Chau-Fong |
| leadposition | Professor |
| leaddepartment | Department of Physiology |
| leadorganisation | College of Medicine, National Taiwan University |
| leadaddress | No. 1, Section 1, Jen-Ai Road, Taipei, Taiwan, ROC. |
| leademail | chfochen@ntumc.org; chfochen@ha.mc.ntu.edu.tw; chfochen@ntu.edu.tw |
| leadphone | +886 2 23222954 |
| leadfax | +886 2 23222954 |
| leadsuffix | |
| contactprefix | |
| contactsurname | |
| contactgivennames | |
| contactposition | |
| contactdepartment | |
| contactorganisation | |
| contactaddress | |
| contactemail | |
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| funding | |
| otherfunding | |
| fundingnameofsponsors | |
| ethicsapproval | yes |
| studytype | nonrandomised |
| studytype_other | |
| groupassignment | |
| blinding_patients | no |
| blinding_investigators | no |
| blinding_outcomes | |
| blinding_analysts | |
| proposedstart | 01/07/2003 |
| actualstart | 01/07/2003 |
| proposedcompletiondate | 03/06/2004 |
| actualcompletiondate | 03/06/2004 |
| multi_center_study | |
| numberofcentres | |
| multi_national_study | |
| countrycentres | Taiwan, Republic of China |
| researchquestion | This study investigates how erythrocytes in hemodialysis patients deal with the large loss of plasma ascorbate with long-term hemodialysis and whether enhanced expression of glucose transporter 1 on erythrocyte membrane in hemodialysis patients plays a role in erythrocyte ascorbate recycling. |
| study_status_recruitment | no_longer_recruiting |
| study_status_recruitment_follow | completed |
| healthcarecondition | end stage renal disease, chronic renal disease |
| intervention1 | hemodialysis in patients with end stage renal disease |
| intervention2 | blood collection before and after hemodialysis |
| intervention3 | |
| intervention4 | |
| participants_gender | both |
| participants_other | adults |
| age | |
| totalrecruitment | 500 |
| inclusion | Patients who had been stable on thrice weekly hemodiaylsis and who had permanent blood access capable of delivering a blood flow rate of at least 200 ml min-1,were eligible for inclusion in the study. |
| exclusion | -diabetes mellitus
-thalassemia -smoker -C-reactive protein level ≧0.6 mg dl-1 -Patient who took angiotensin-converting enzyme inhibitor (ACEI), oral and intravenous vitamins or iron were also excluded. |
| primaryoutcomes | Comparison of intra-erythrocyte ascrobate and DHA concentrations, GLUT 1 expression levels on EM and in vitro studies of ?erythrocyte ascorbate recycling? in age- and sex- matched healthy subjects and HD patients pre- and post-hemodialysis |
| secondaryoutcomes | Comparison of ascorbate-preserving ability for erythrocytes in different study groups |
| reference |